Health Outcomes, Epidemiology and Biostatistics Consulting

Perisphere RWE Mission

We make scientific discoveries and improve health outcomes by applying advanced epidemiology and statistical tools to generate real-world evidence.

Dr. Paul Muntner

Founder, Perisphere real-world evidence, LLC.

Dr. Paul Muntner has over 20 years of experience conducting pharmacoepidemiology research. He earned a Master’s of Health Science in Biostatistics and Doctor of Philosophy in Epidemiology from the Johns Hopkins Bloomberg School of Public Health. From 2000 to 2023, he served as a faculty member at Tulane University School of Public Health and Tropical Medicine, Mount Sinai School of Medicine, and the University of Alabama at Birmingham (UAB) School of Public Health. At UAB, he served as the Co-director of the Pharmacoepidemiology and Economics Research Unit and Associate Dean for Research at the School of Public Health. Dr. Muntner has led studies across the drug lifecycle including providing data to support FDA filings for initial approval and post-approval label expansion. He has published over 600 peer-reviewed journal articles.

Pharmacoepidemiology Expertise

  • Over 20 years experience generating real-world evidence (RWE).
  • Government experience – Acting Chief Science Officer for the Centers for Disease Control and Prevention (CDC).
  • Analyzing large claims datasets for FDA filings and regulatory requirements.
  • Implementing and leading data coordinating centers.
  • Member and chair of guideline and Scientific Statement committees.
  • Over 700 peer-reviewed publications in top medical journals (cited >100,000).

We Move Research
Beyond Publications

  • Primary data collection
  • Advanced data analytics
  • Cost-effectiveness analyses
  • Guideline implementation
  • Policy modeling
  • Engagement with key opinion leaders
  • Engagement with policy makers

Project Examples

Staging and clean room: Constructs designed to facilitate transparency and reduce bias in comparative analyses of real-world data.

Pragmatic considerations for negative control outcome studies to guide non-randomized comparative analyses: A narrative review.

Lipid-Lowering Therapy Use and Intensification Among United States Veterans Following Myocardial Infarction or Coronary Revascularization

Development of algorithms for identifying fatal cardiovascular disease in Medicare claims.

Comparative effects of biologics on cardiovascular risk among older patients with rheumatoid arthritis

We Have Experience Providing
Evidence Across a Product Life Cycle

Pre-Market

  • Population sizing
  • Unmet treatment needs
  • Cost analyses
  • Assessing/guidance on trial inclusion criteria
  • Background adverse event rates

Post Approval

  • Comparative effectiveness
  • Adherence
  • Label expansion
  • Evaluation of possible safety signals

Our Capabilities

  • Study design and protocol development
  • Questionnaire development
  • Database development and implementation
  • Statistical analysis and machine learning
  • Qualitative data collection
  • Data linkage and claims data algorithm validation
  • Systematic reviews
  • Data visualization

Career Opportunities

Associate Director of Data Analytics

Perisphere Real World Evidence, Associate Director of Data Analytics

Download a PDF verson of this career opportunity

Perisphere Real World Evidence (www.perisphere-rwe.com) was founded to address the increasing demand for real-world evidence from regulatory and reimbursement authorities. The team at Perisphere conducts rigorous research to translate data into real world evidence that provide insight into the development of new medications, safety and effectiveness evaluation of medications, unmet treatment needs, and barriers to optimal health.

The scientists at Perisphere work collaboratively with our clients from biopharmaceutical companies and academia to design, conduct, interpret and publish research using data that informs drug development, the design of clinical trials, and safety and real-world efficacy. We are passionate about making scientific discoveries and helping patients and are looking for driven professionals who share our vision. We value clarity, communication, and continuous improvement in our approach to working with collaborators.

As the Associate Director of Data Analytics, you will use your skills, experience, and passion to make discoveries that improve health and lives of patients through the analysis of real-world evidence. You will work on projects that enable patients to receive the care they need faster. At Perisphere Real World Evidence, we work with the leading biotechnology and pharmaceutical companies worldwide to support drug discovery, accelerating drug development and monitoring drug use and safety. Projects include but are not limited to a focus on burden of disease, natural history of disease, and safety and effectiveness. In long-term collaborations, there may be the opportunity to develop and implement cutting-edge statistical methods.

The Associate Director of Data Analytics will lead rigorous statistical analyses of data across the drug lifecycle and delivery of healthcare. In addition, the successful candidate will contribute to business development and staff training at Perisphere Real World Evidence.

Key Activities include:

  • Design and conduct statistical analysis of multiple types of data including healthcare claims, electronic health record data, and prospective observational cohort studies.
  • Prepare and review statistical analysis plans
  • Draft analysis sections of proposals and reports
  • Review and provide feedback on reports
  • Develop training material for statisticians and programmers.
  • Contribute to the development/implementation of the company’s computing environment.
  • Provide support and mentorship for co-workers in the rigorous conduct of research.
  • Support clients in the implementation of data management and statistical analyses.
  • Work with the leadership team to develop and implement company policies.
  • Assist with on-boarding new staff.
  • Communicate scientific information to co-workers, clients, researchers and clinicians.

Qualifications

  • Master’s degree in biostatistics, statistics or closely related field with at least 7 years of experience in the statistical analysis of real-world data
  • At least 3 years of experience conducting data management and statistical programming of claims data. Strong preference for experience working with Medicare claims
  • Advanced programming skills in SAS and R
  • Ability to develop and maintain dynamic documents for reproducible research using R-markdown or Quarto
  • Comfortable using git and GitHub for version control
  • Familiarity with observational research study designs
  • Experience working on studies related to drug development and use including new user designs and medication adherence
  • Experience developing training materials for statisticians and programmers
  •  Track record for preparing documentation of statistical programs
  • Excellent verbal communication and interpersonal skills
  • Experience working in multi-disciplinary teams
  • Strong skills with MS Outlook, Word and Excel

In addition to a competitive salary, Perisphere Real-World Evidence offers:

  • An employee benefits package including health insurance and contribution to a retirement savings account
  • An annual bonus program
  • Paid time off
  • Remote work arrangement within the US

How to Apply

Perisphere Real World Evidence is an Equal Opportunity employer and will consider applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. Perisphere Real World Evidence is not sponsoring new employees in application of the H-1B Visa at this time. All applicants must be legally authorized to work in the United States under the Immigration and Reform Control Act of 1986.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

To apply, please submit a resume and cover letter describing relevant professional work experience to hiring@perisphere-rwe.com. Include Associate Director of Data Analytics in the subject line. Incomplete applications will not be considered.

Assistant Director of Real-world Data Research

Perisphere Real World Evidence, Assistant Director of Real-world Data Research

Download PDF Version of this Career Opportunity

Perisphere Real World Evidence (www.perisphere-rwe.com) was founded to address the increasing demand for real-world evidence from regulatory and reimbursement authorities. The team at Perisphere conducts rigorous research to translate real world data into real world evidence that provide insight into the development of new medications, safety and effectiveness evaluation of medications, unmet treatment needs, and barriers to optimal health.

The scientists at Perisphere work collaboratively with our clients from biopharmaceutical companies to design, conduct, interpret and publish research using real-world data that informs drug development, the design of clinical trials, and safety and real-world efficacy. Projects include but are not limited to a focus on burden of disease, natural history of disease, safety and effectiveness and the development and application of cutting-edge statistical methods.

In this role, you will use your skills, experience, and passion to make discoveries that improve health and lives of patients through the application of real-world evidence. You will work on projects that enable patients to receive the care they need faster. At Perisphere Real World Evidence, we work with the leading biotechnology and pharmaceutical companies worldwide to support drug discovery, accelerating drug development and monitoring drug use and safety. We are passionate about making scientific discoveries and helping patients and are looking for driven professionals who share our vision.

The Assistant Director of Real-world Data Research will contribute to rigorous scientific studies using real world data across the drug lifecycle and delivery of healthcare. In addition, the successful candidate will contribute to the strategic growth at Perisphere Real World Evidence.

Key Activities include:

  • Design and conduct real-world data research studies on risk factors and diseases and approaches to improve patient outcomes.
  • Design and conduct statistical analysis of multiple types of data including healthcare claims, electronic health record data, and prospective observational cohort studies.
  • Prepare research protocols and statistical analysis plans
  • Conduct systematic literature reviews
  • Write and edit research reports and manuscripts
  • Monitor and apply new methods for conducting observational research.
  • Provide scientific mentorship to co-workers.
  • Communicate scientific information to co-workers, clients, researchers and clinicians.

Qualifications:

  • Doctorate degree with at least 2 years of post-doctoral experience in the design and conduct of real-world data or Master’s degree with at least 5 years of scientific experience in real-world data.
  • Familiarity on research studies supporting drug development and use
  • Prior experience designing and conducting research using administrative healthcare claims (e.g., Medicare) and electronic health record data
  • Experience in observational research project planning and management
  • Excellent verbal and writing communication and interpersonal skills including first author publications
  • Facility with PowerPoint slide making and unique ability to communicate critical scientific information succinctly
  • Experience working in multi-disciplinary teams
  • Strong skills with SAS, Stata or R programming languages and MS Word and Excel

In addition to a competitive salary, Perisphere Real-World Evidence offers:

  • An employee benefits package including health insurance and contribution to a retirement savings account
  • An annual bonus program
  • Paid time off
  • Remote work arrangement within the US

Assistant Director of Real-world Data Research

Perisphere Real World Evidence is an Equal Opportunity employer and will consider applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. Perisphere Real World Evidence is not sponsoring new employees in application of the H-1B Visa at this time. All applicants must be legally authorized to work in the United States under the Immigration and Reform Control Act of 1986.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

To apply, please submit a resume and cover letter describing relevant professional work experience to hiring@perisphere-rwe.com. Include Assistant Director of Real-world Data Research in the subject line. We will not consider incomplete applications and will only contact qualified candidates.

Why Work With Us

Collaborative, engaging leaders as partners

Innovative, using advanced scientific methods

Productive, achieving high scientific productivity

Impactful, disseminating broadly through publications